C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/74 (2006.01) A61K 39/112 (2006.01) C07K 14/255 (2006.01) C12N 1/20 (2006.01) C12N 15/01 (2006.01) C12Q 1/68 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2097931
The present invention provides for vaccines and bacteria which are virulence attenuated by mutations in a two-component regulatory system. In particular, the present invention relates to vaccines comprising Salmonella cells with attenuated virulence, involving induced mutations in the phoP regulatory region and/or the pag or prg genes. The virulence attenuation of the present invention does not involve the insertion of an antibiotic resistance gene into the Salmonella genone.
Mekalanos John J.
Miller Samuel I. III
Kirby Eades Gale Baker
President And Fellows Of Harvard College
The General Hospital Corporation
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