Salt forms of atorvastatin

Details Salt forms of atorvastatin Salt forms of atorvastatin

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2567931

Novel salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-.szlig.,.delta.-dihydroxy-5- (1-methylethyl)-3-phenyl-4~[(phenylamino)carbonyl]-1 H-pyrrole-1-heptanoic acid or solvates or hydrates thereof, as well as crystalline salts characterized by their X-ray powder diffraction pattern are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease.

La présente invention concerne de nouvelles formes salines d'acide [R-(R*,R*)]-2-(4-fluorophényl)-.szlig.,d-dihydroxy-5-(1-méthyléthyl)-3-phényl-4-[(phénylamino)carbonyl]-1H-pyrrole-1-heptanoïque ou des solvates ou hydrates de celui-ci, ainsi que des sels cristallins se caractérisant par leur motif de diffraction sur poudre aux rayons X, des procédés pour les préparer, et une composition pharmaceutique de ceux-ci, ces composés étant utiles en tant qu'agents pour traiter l'hyperlipémie, l'hypercholestérolémie, l'ostéoporose, l'hyperplasie prostatique bénigne, et la maladie d'Alzheimer.

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