Salt forms of [r-(r*, r*)]-2-(4-fluorophenyl)-.beta.,...

Details Salt forms of [r-(r*, r*)]-2-(4-fluorophenyl)-.beta.,... Salt forms of [r-(r*, r*)]-2-(4-fluorophenyl)-.beta.,...

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2564030

Novel salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5- (1-methylethyl)-3-phenyl-4~[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease.

La présente invention concerne de nouvelles formes salines d'acide [R-(R*,R*)]-2-(4-fluorophényl)-.beta.,.delta.-dihydroxy-5-(1-méthyléthyl)-3-phényl-4-[(phénylamino)carbonyl]-1H-pyrrole-1-heptanoïque caractérisées par leur motif de diffraction des poudres aux rayons X et leurs spectres de résonance magnétique nucléaire à l'état solide. Cette invention concerne également des procédés pour préparer ces formes salines, ainsi que des compositions pharmaceutiques de celles-ci, qui sont utilisées en tant qu'agents pour traiter une hyperlipémie, une hypercholestérolémie, une ostéoporose, une hyperplasie bénigne de la prostate et la maladie d'Alzheimer.

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