C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 303/48 (2006.01)
Patent
CA 2523233
It is intended to purify (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3- methylbutyl]carbamoyl]oxirane-2-carboxylic acid (hereinafter referred to as ~carboxylic acid~) with the use of a salt from the carboxylic acid and an organic amine selected from among piperazine, adamantanamines, etc. and to provide a crystalline sodium salt of the carboxylic acid which has the following properties and is enhanced in storage stability so as to be suitable for use as a raw material for medicinal drug. DSC: 170 to 175~C exothermic peak accompanied by weight loss Characteristic absorption bands in infrared absorption spectrum (potassium bromide tablet method): 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm-1.
L'invention concerne la purification de l'acide (2S,3S)-3-[[(1S)-1-isobutoxyméthyl-3-méthylbutyl]carbamoyl]oxyrane-2-carboxylique (ci-après appelé <= acide carboxylique >=) avec utilisation d'un sel de l'acide carboxylique et un amine organique choisi parmi pipérazine, adamantanamines, etc. Elle concerne également un sel de sodium cristallin de l'acide carboxylique qui présente les propriétés suivantes et dont la stabilité de stockage est améliorée de façon à pouvoir servir de matière première de médicaments. DSC : crête exothermique de 170 à 175 ·C accompagné de perte de poids. Bandes d'absorption caractéristique dans le spectre d'absorption infrarouge (procédé de comprimés de bromure de potassium) : 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?-1¿.
Nihashi Susumu
Okai Kazuki
Takahashi Toshihiro
Tendo Atsushi
Yamakawa Tomio
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Nippon Chemiphar Co. Ltd.
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