Salt of abt-263 and solid-state forms thereof

Details Salt of abt-263 and solid-state forms thereof Salt of abt-263 and solid-state forms thereof

C - Chemistry, Metallurgy

07

D

C07D 295/155 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2758740

ABT-263 bis-HCl and crystalline polymorphs thereof are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

L'invention porte sur le bis-HCl d'ABT-263 et sur des polymorphes cristallins de celui-ci qui sont des ingrédients pharmaceutiques actifs appropriés pour des compositions pharmaceutiques utiles dans le traitement d'une maladie caractérisée par une surexpression d'une ou plusieurs protéines de la famille Bcl-2 anti-apoptotique, par exemple le cancer.

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