Salt of diclofenac with a cyclic organic base and...

Details Salt of diclofenac with a cyclic organic base and... Salt of diclofenac with a cyclic organic base and...

C - Chemistry, Metallurgy

07

D

167/233, 260/325

C07D 295/088 (2006.01) A61K 31/40 (2006.01)

Patent

CA 1303050

ABSTRACT Salts of diclofenac (2-[2,6-dichlorophenyl)-amino]-benzeneacetic acid) with a cyclic organic base having the general formula (I) Image (I) in which X is a group of the formula (CH2)m, in which m is 0, 1 or 2 or X is oxygen, sulfur or NR, R being an alkyl group C2- C4, and n is 2 or 3, are useful in antiinflammatory pharmaceutical compositions. Such salts are prepared by dissolving diclofenac in a suitable organic solvent, adding said cyclic organic base, reacting the two components together, removing the solvent and crystallizing the product obtained.

551717

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