Salt of phenoxypyridine derivative or crystal thereof and...

Details Salt of phenoxypyridine derivative or crystal thereof and... Salt of phenoxypyridine derivative or crystal thereof and...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4427 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2661333

It is intended to provide an acid addition salt of a compound represented by the formula (1) or (2) or a crystal thereof and a process for producing the same. Such a salt or crystal has an HGFR inhibitory action and excellent physical properties (solubility, safety, etc.), therefore, it is useful as an antitumor agent for various tumors, an angiogenic inhibitor or a cancer metastasis inhibitor.

La présente invention concerne un sel d'addition acide d'un composé de formule (1) ou (2) ou de son cristal, ainsi que leur procédé de production. Un tel sel ou cristal présente une action inhibitrice de HGFR ainsi que d'excellentes propriétés physiques (solubilité, innocuité, entre autres.), ce qui permet de l'employer en tant qu'agent antitumoral dans le traitement de diverses tumeurs, en tant qu'inhibiteur de l'angiogenèse ou en tant qu'inhibiteur de métastases cancéreuses.

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