C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/496 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2598301
Disclosed is a compound of 3-{(2S,4S)-4-[4-(3-methyl-1-phenyl- 1H-pyrazole-5- yl)piperazine-1-yl]pyrrolidine-2-ylcarbonyl} thiazolidine (compound I) which is useful as a dipeptidyl peptidase IV inhibitor. This compound has excellent characteristics in stability and moisture absorption, while having a reproducible crystal structure. Also disclosed is a method for producing such a compound.
La présente invention concerne un dérivé de 3-{(2S,4S)-4-[4-(3-méthyl-1-phényl-1H-pyrazol-5-yl)pipérazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidin (composé I) pouvant être employé en tant qu'inhibiteur de la dipeptidylpeptidase IV. Ce composé présente d'excellentes caractéristiques en termes de stabilité et d'absorption d'humidité, tout en présentant une structure cristalline reproductible. La présente invention décrit également une méthode de synthèse d'un tel composé.
Akahoshi Fumihiko
Kirihara Shinji
Sakashita Hiroshi
Tsutsumiuchi Reiko
Ueda Naoko
Fetherstonhaugh & Co.
Mitsubishi Pharma Corporation
Mitsubishi Tanabe Pharma Corporation
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