C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2749702
The present invention provides a crystal of a 1.5 D-tartrate of a compound represented by the formula (1) having an A production inhibitory effect, characterized in that the crystal has a diffraction peak at a diffraction angle (2 0.2 ) of 23.2 in powder X-ray diffractometry; a crystal of a disulfate of the compound of the formula (1), characterized in that the crystal has a diffraction peak at a diffraction angle (2 0.2 ) of 17.1 in powder X-ray diffractometry; various other salts of the compound of the formula (1); crystal polymorphs of these salts; and the like, which are expected to be used as drug substances.
La présente invention porte sur des cristaux d'un 1.5 D-tartrate d'un composé représenté par la formule (1) ayant un effet d'inhibition de la production de A, caractérisés en ce que les cristaux ont un pic de diffraction à un angle de diffraction (2 0.2) de 23,2 en diffractométrie par rayons X sur poudre ; sur des cristaux d'un disulfate du composé représenté par la formule (1), caractérisés en ce que les cristaux ont un pic de diffraction à un angle de diffraction (2 0.2) de 17,1 en diffractométrie par rayons X sur poudre ; sur divers autres sels du composé représenté par la formule (1) ; sur des polymorphes cristallins de ces sels ; et similaire, dont on s'attend à ce qu'ils soient utilisés comme substances médicamenteuses.
Kitazawa Noritaka
Kushida Ikuo
Minamisono Takuma
Eisai R&d Management Co. Ltd.
Smart & Biggar
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