Salts forms of 4-phenylamino quinazoline derivative

Details Salts forms of 4-phenylamino quinazoline derivative Salts forms of 4-phenylamino quinazoline derivative

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2677978

The salts of N-{4-[3-chloro-4-(3-fluoro-benzyloxy)phenylamino]-quinazoline-6-yl}- acrylamide, preparation methods, compositions containing the same and their uses thereof. The present salts have excellent anti-tumour activity, good bioavailability in vitro and in vivo in animals and low toxicity, so they are suitable for anti-tumour medicaments.

Les sels de N-{4-[3-chloro-4-(3-fluoro-benzyloxy)phenylamino]-quinazoline-6-yl}- acrylamide, leurs procédés de préparation, les compositions les contenant et leurs utilisations. Les sels font preuve d'une excellente activité antitumorale, d'une bonne biodisponibilité in vitro et in vivo chez les animaux et d'une faible toxicité, ce qui en fait des médicaments antitumoraux.

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