C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/438 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2670858
The present invention is directed to salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by NOP, for example depression, anxiety, alcohol abuse, etc. The present invention is further directed to process(es) for the preparation of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one and its corresponding salts.
La présente invention concerne des sels de la 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phényl)-8-(8-méthyl-naphtalén-1-ylméthyl)-1,3,8-triaza-spiro[4,5]décan-4-one, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement de troubles et de conditions provenant de la NOP, par exemple, la dépression, l'anxiété, l'abus d'alcool, etc. La présente invention concerne en outre un ou plusieurs procédés de préparation de la 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phényl)-8-(8-méthyl-naphtalén-1-ylméthyl)-1,3,8-triaza-spiro[4,5]décan-4-one et des sels correspondants.
Faessler Roger
Hegyi Jean Francois Alexandre Lucas
Mehrman Steven J.
Roessler Armin
Villani Frank J.
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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