Salts of 3-(cis-2,6-dimethylpiperidino)sydnone imine

Details Salts of 3-(cis-2,6-dimethylpiperidino)sydnone imine Salts of 3-(cis-2,6-dimethylpiperidino)sydnone imine

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/445 (2006.01) C07D 271/04 (2006.01)

Patent

CA 2096327

23233-276 ABSTRACT The present invention relates to 3-(cis-2,6- dimethylpiperidino)sydnone imine salts of the general formula I. Image (I) in which X denotes H2PO4 or Image processes for their preparation and their use. The salts of formula I are not hygroscopic, which makes them more suitable for the preparation of pharmaceutical compositions. In aqueous solutions they set a weakly acidic pH, favourable for the stability of the sydnone imine and acceptable for parenteral administration. They lower the blood pressure, the pulmonary artery pressure and the left ventricular end-diastolic pressure, without provoking reflex tachycardia, thus being useful in the control or prevention of disorders of the cardiovascular system.

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