C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2575718
The invention provides (1) a process for the production of alkali metal salts of 2-[{4-(3-methoxypropoxy)-3- methylpyridin-2-yl}methylsulfinyl]-1H- benzimidazole which are useful as gastric acid secretion inhibitor, antiulcer agent, and other drugs and (2) salts of 2-[{4-(3-methoxypropoxy) -3- methylpyridin-2-yl}methylsulfinyl]-1H- benzimidazole with amines which are intermediates for the production of the alkali metal salts and a process for the production of the same. Specifically, salts represented by the general formula (.IOTA.): wherein A+ is an isopropylammonium ion, a sec-butylammonium ion, or a cyclopentylammonium ion.
L'invention concerne (1) un procédé de production de sels de métal alcalin de 2-[{4-(3-méthoxypropoxy)-3-méthylpyridin-2-yl}méthylsulfinyl]-1H-benzimidazole qui sont utiles comme inhibiteurs de la sécrétion d'acide gastrique, agent antiulcéreux, et autres médicaments et (2) des sels de 2-[{4-(3-méthoxypropoxy)-3-méthylpyridin-2-yl}méthylsulfinyl]-1H-benzimidazole avec des amines qui sont des intermédiaires de production des sels de métal alcalin et un procédé de production de ceux-ci. Spécifiquement, elle concerne les sels représentés par la formule générale (|) : (|) où A<SUP>+</SUP> est un ion isopropylammonium, un ion sec-butylammonium, ou un ion cyclopentylammonium.
Haga Toyokazu
Mizuno Masanori
Yokoi Hiroyuki
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Eisai R. & D. Management Co. Ltd.
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