Salts of isobutyric acid (1 r*, 2r*, 4r* ) -2- (2-{ [3- (4,...

Details Salts of isobutyric acid (1 r*, 2r*, 4r* ) -2- (2-{ [3- (4,... Salts of isobutyric acid (1 r*, 2r*, 4r* ) -2- (2-{ [3- (4,...

C - Chemistry, Metallurgy

07

D

C07D 235/14 (2006.01) A61K 31/4184 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2740722

The invention relates to crystalline salts of isobutyric acid (1R*,2R*,4R*)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimi-dazol-2-yl)-propyl]-methyl- amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester, processes for the preparation thereof, phar-maceutical compositions containing said crystalline salts, and their use as medicaments, especially as calcium channel blockers.

La présente invention concerne des sels cristallins de lester du (1R*,2R*,4R*)-2-(2-{[3-(4,7-diméthoxy-1H-benzoimidazol-2-yl)-propyl]-méthyl-amino}-éthyl)-5-phényl-bicyclo[2.2.2]oct-5-èn-2-yle de lacide isobutyrique, des procédés pour leur préparation, des compositions pharmaceutiques contenant lesdits sels cristallins, et leur utilisation comme médicaments, en particulier comme bloqueurs de canaux calciques.

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