Salts of nefazodone having improved dissolution rates

Details Salts of nefazodone having improved dissolution rates Salts of nefazodone having improved dissolution rates

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/495 (2006.01) C07D 249/12 (2006.01)

Patent

CA 2160423

The L-malate, L-tartrate and methane sulfonate salts of nefazodone showed significantly higher intrinsic dissolution in water and THAM buffer compared to other salts of nefazodone. The faster dissolution rates of these salts at higher pH's may suggests better dissolution and absorption in the intestine, and improved bioavailability for oral formulations.

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