Salts of phenyl-alkanoic acids

C - Chemistry – Metallurgy – 07 – C

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260/515.3, 260/5

C07C 59/84 (2006.01) C07C 57/30 (2006.01) C07C 57/46 (2006.01) C07C 59/64 (2006.01) C07C 59/68 (2006.01)

Patent

CA 1070324

ABSTRACT OF THE DISCLOSURE The present invention relates to salts of the general formula:- Image wherein R1 and R2, which may be the same or different, are hy- drogen atoms or lower alkyl radicals, R3 is a halogen atom or an alkyl radical containing up to 5 carbon atoms, which may be straight-chained or branched, or is an alkoxy, alkenyloxy or cyclo- alkyl radical or is a phenyl, phenoxy or benzoyl radical, the aromatic nucleus of which may be substituted by one or more halo- gen atoms, R4 is a hydrogen or halogen atom or an alkyl radical containing up to 5 carbon atoms, which may be straight-chained or branched, or is an alkoxy, alkenyloxy or cycloalkyl radical or is a phenyl, phenoxy or benzoyl radical, the aromatic nucleus of which may be substituted by one of more halogen atoms, or R3 and R4 together represent a fused aromatic ring containing a methoxy substituent, B is a primary, secondary or tertiary amino group or a guanidino or amidino group and n is a whole number not greater than 5. These salts are useful as analgesic and anti- inflammatory agents. The disclosure also relates to the prepara- tion of these salts.

221604

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