Salts of potassium atp channel openers and uses thereof

Details Salts of potassium atp channel openers and uses thereof Salts of potassium atp channel openers and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 285/24 (2006.01) A61K 31/549 (2006.01) A61P 3/04 (2006.01) C07C 215/40 (2006.01)

Patent

CA 2636274

Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

La présente invention concerne l'administration immédiate ou prolongée de certains sels d'ouvreurs des canaux KATP tels que le diazoxyde à un sujet afin d'obtenir de nouveaux résultats pharmacodynamiques, pharmacocinétiques, thérapeutiques, physiologiques, métaboliques et compositionnels dans le traitement de maladies ou d'affections impliquant les canaux KATP. La présente invention concerne également des formulations pharmaceutiques, des procédés d'administration et de dosage des sels qui donnent ces résultats et réduisent l'incidence des effets défavorables chez les individus traités. La présente invention concerne en outre un procédé de co-administration des sels avec d'autres médicaments pour traiter des maladies chez l'homme et les animaux.

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