Salts of potassium atp channel openers and uses thereof

Details Salts of potassium atp channel openers and uses thereof Salts of potassium atp channel openers and uses thereof

A - Human Necessities

61

K

A61K 31/549 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2692160

Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

L'invention porte sur une administration immédiate ou prolongée de certains sels d'ouvreurs de canaux potassiques sensibles à l'ATP (KATP) de sels de KATP tels que le diazoxyde à un sujet pour obtenir de nouveaux résultats pharmacodynamiques, pharmacocinétiques, thérapeutiques, physiologiques, métaboliques et de composition dans le traitement de maladies ou d'états mettant en jeu des canaux KATP. L'invention porte sur des formulations pharmaceutiques, sur des procédés d'administration et de dosage des sels qui permettent d'obtenir ces résultats et réduisent l'incidence des effets secondaires dans les individus traités. L'invention porte en outre sur des procédés de coadministration des sels avec d'autres médicaments pour traiter des maladies des êtres humains et des animaux.

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