Salts of pyridazine compounds

Details Salts of pyridazine compounds Salts of pyridazine compounds

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2650704

The invention relates to stable and substantially purified synthetic pharmaceutically acceptable acid addition salts of pyridazine compounds of the formula I wherein R10 is hydrogen, hydroxyl, alkyl, alkoxy, alkenyl, alkynyl, alkylene, aryl, heteroaryl, sulfonyl, sulfinyl, sulfenyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, =0, =S, carboxyl, carbonyl, carbamoyl, carboxamide, or phosphonate, and R11 is alkyl, alkoxy, alkenyl, alkynyl, alkylene, alkenylene, alkenyloxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, sulfonyl, sulfinyl, sulfenyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, =0, =S, phosphonate, carboxyl, carbonyl, carbamoyl, carboxamide, or ureido. The invention also relates to formulations, dosage forms and compositions comprising the salts, and methods of using the salts, formulations, dosage forms and compositions.

L'invention concerne des sels d'addition d'acide acceptables du point de vue pharmaceutique synthétiques stables et en grande partie purifiés de composés de pyridazine de formule I dans laquelle R10 est un hydrogène, un hydroxyle, un alkyle, un alcoxy, un alcényle, un alcynyle, un alkylène, un aryle, un hétéroaryle, un sulfonyle, un sulfinyle, un sulfényle, un amino, un imino, un azido, un thiol, un thioalkyle, un thioalcoxy, un thioaryle, un nitro, un cyano, un halogéno, =O, =S, un carboxyle, un carbonyle, un carbamoyle, un carboxamide ou un phosphonate et R11 est un alkyle, un alcoxy, un alcényle, un alcynyle, un alkylène, un alcénylène, un alcényloxy, un aryle, un aryloxy, un arylalcoxy, un aroyle, un hétéroaryle, un groupe hétérocyclique, un acyle, un acyloxy, un sulfonyle, un sulfinyle, un sulfényle, un amino, un imino, un azido, un thiol, un thioalkyle, un thioalcoxy, un thioaryle, un nitro, un cyano, un halogéno, =O, =S, un phosphonate, un carboxyle, un carbonyle, un carbamoyle, un carboxamide ou un uréido. L'invention concerne également des formulations, des formes de dosage et des compositions comprenant les sels et des procédés d'utilisation des sels, des formulations, des formes de dosage et des compositions.

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