Salts of tricyclic inhibitors of poly(adp-ribose) polymerases

Details Salts of tricyclic inhibitors of poly(adp-ribose) polymerases Salts of tricyclic inhibitors of poly(adp-ribose) polymerases

C - Chemistry, Metallurgy

07

D

C07D 487/06 (2006.01) A61K 31/55 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2520997

Pharmaceutically acceptable salts of compounds of the formula (I) below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.

Les sels pharmaceutiquement acceptables de composés de la formule ci-dessous sont des inhibiteurs de poly(ADP-ribosyl)transferase (PARP), et sont utiles comme agents thérapeutiques dans le traitement de cancers et l'atténuation des effets des accidents vasculaires cérébraux, des traumatismes crâniens et des maladies neurodégénératives. En tant qu'agents thérapeutiques pour le traitement du cancer, les composés selon l'invention peuvent s'utiliser, par exemple, en combinaison avec des agents cytotoxiques et/ou la radiothérapie.

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