Salts of trimebutine and n-desmethyl trimebutine

Details Salts of trimebutine and n-desmethyl trimebutine Salts of trimebutine and n-desmethyl trimebutine

C - Chemistry, Metallurgy

07

C

C07C 219/14 (2006.01) A61K 31/24 (2006.01) A61P 29/00 (2006.01) C07C 213/08 (2006.01) C07C 327/48 (2006.01) C07D 339/04 (2006.01)

Patent

CA 2653869

Unique salts of trimebutine and N-monodesmethyl trimebutine, and their corresponding stereoisomers, having improved analgesic properties useful in the treatment of visceral pain are provided. The salts of the present invention are particularly useful in the treatment of conditions characterized by abdominal pain, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), diabetic gastroparesis, and dyspepsia.

La présente invention concerne des sels spécifiques de trimébutine et de N-monodéméthyltrimébutine, ainsi que leurs stéréoisomères correspondants, lesdits composés présentant des propriétés analgésiques améliorées utiles dans le traitement de la douleur viscérale. Les sels selon la présente invention sont particulièrement utiles dans le traitement d'états pathologiques caractérisés par une douleur abdominale, par exemple l'affection abdominale inflammatoire (AAI) et le syndrome du côlon irritable (SCI), la gastroparésie diabétique et la dyspepsie.

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