Salts with crth2 antagonist activity

Details Salts with crth2 antagonist activity Salts with crth2 antagonist activity

C - Chemistry, Metallurgy

07

D

C07D 209/10 (2006.01) A61K 31/405 (2006.01) A61P 29/00 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2646002

The potassium, sodium, ammonium, lysine, diethylamine, tromethamine (TRIS), piperazine, ethylenediamine and ethanolamine salt of a compound of general formula (I): wherein R1 is halo or cyano; R2 is C1-C4 alkyl; and R3 is quinolyl or phenyl substituted with methane sulfonyl; can be synthesised by a novel method and are substantially more soluble than the parent free acids in a range of solvents.

La présente invention concerne les sels de potassium, sodium, ammonium, lysine, diéthylamine, trométhamine (TRIS), pipérazine, éthylène diamine et éthanolamine d'un composé répondant à la formule générale (I) : R1 est un atome d'halogène ou un groupe cyano ; R2 est un groupe alkyle en C1 à C4 ; et R3 est un groupe quinolyle ou phényle substitué par un groupe méthane sulfonyle ; les sels peuvent être synthétisés à l'aide d'un nouveau procédé et ils sont sensiblement plus solubles que les acides libres parents dans une gamme de solvants.

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