Sam-6 variants, target and methods of use

Details Sam-6 variants, target and methods of use Sam-6 variants, target and methods of use

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2751571

The application relates to variants and functional fragments of the SAM-6 antibody that bind to one or more of glucose regulated protein 78 (Grp78), deglycosylated Grp78, apolipoprotein B 100 (apoB 100), and glycosylated or deglycosylated lipoproteins VLDL and LDL. Use of the variants and functional fragments in the treatment and diagnosis of neoplasia, tumour, cancer and disorders or diseases associated with excessive levels of LDL or oxidised LDL is also described.

L'invention concerne des variants et des fragments fonctionnels de l'anticorps SAM-6 qui se fixent à une ou à plusieurs protéines parmi la protéine régulée par le glucose 78 (Grp78), la Grp78 déglycosylée, l'apolipoprotéine B100 (apoB100) et les lipoprotéines VLDL et LDL glycosylées ou déglycosylées. L'invention porte également sur l'utilisation des variants et des fragments fonctionnels dans le traitement et le diagnostic d'une néoplasie, d'une tumeur, d'un cancer et de troubles ou de maladies associés à des taux excessifs de LDL ou de LDL oxydé.

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