Sample deposition method and system

B - Operations – Transporting – 01 – L

Patent

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Details

B01L 3/00 (2006.01) B01L 3/02 (2006.01) G01N 1/14 (2006.01) G01N 1/18 (2006.01) H01J 49/04 (2006.01) G01N 30/84 (2006.01)

Patent

CA 2434305

This invention provides methods and systems for rapidly, accurately and efficiently depositing liquid droplets (130) onto a planar uper surface (117) of sample plate (115) held in sample plate holder (110) which is supported on, or incorporated into, a motion table (105) included in an LC MALDI sample distribution system (100) for MALDI-mass spectrometry sample preparation. System (100) also includes a holding mechanism (118) for holding at least one capillary (125) which terminates at a capillary tip (127) on which droplet (130) is formed. A power supply (135) forms an electric field between sample plate surface (117) and droplet (130) which acts to pull the droplet (130) onto the sample plate (115).

L'invention concerne des procédés et des systèmes pour déposer de façon efficace, précise et rapide des gouttes de liquide (130) sur la surface plane supérieure (117) d'une plaque échantillon (115) disposée dans un support (110), lequel est logé sur ou incorporé à une table mobile (105) faisant partie d'un système (100) de diffusion d'échantillons MALDI LC pour la préparation d'échantillons de spectrométrie de masse MALDI. Ce système (100) comporte également un mécanisme de fixation (118) pour maintenir au moins un capillaire (125) qui se termine par une pointe capillaire (127), sur laquelle se forme une goutte (130). Une alimentation électrique (135) génère un champ électrique entre la surface (117) de la plaque échantillon et la goutte (130), ce champ électrique attirant la goutte (130) vers la plaque échantillon (115).

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