Saposin c and receptors as targets for treatment of benign...

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A61K 38/00 (2006.01) C07K 14/415 (2006.01) C07K 14/475 (2006.01)

Patent

CA 2510313

Saposin C was shown to be a trophic factor for a variety of cancer cells, e.g., prostate, lung, breast, and colon cancer cells. These cells expressed saposin C and responded to saposin C by increased levels of cell proliferation, cell migration, and cell invasion. Such activities typify and promote the neoplastic process. A conjugate of a peptide of the active region of saposin C (TX14A) and a toxin (saporin) was made and was shown to decrease the survival of prostate cancer cells, and the other cancer cells that were found to express saposin C (including cancers cells of the breast, colon, and lung). This conjugate or a compound of analogous action that inhibits cellular growth acting via a saposin-C binding receptor can be used to decrease tumor growth and/or treat disorders of stromal proliferation (e.g., benign prostatic hyperplasia, atherosclerosis, and vascular restenosis).

La saposine C s'est avérée être le facteur trophique d'une variété de cellules cancéreuses, par exemple de la prostate, des poumons, et du colon. Lesdites cellules exprimant la saposine C répondent à la saposine C par un accroissement de la prolifération, de la migration, et de l'invasion des cellules, de telles activités étant typiques du processus néoplasique et le promouvant. Un conjugué d'un peptide de la région active de la saposine C (TX14A) et d'une toxine (saporine) ayant été obtenu, a montré qu'il réduisait la survie des cellules cancéreuses de la prostate et d'autres cellules s'étant avérées exprimer la saposine, dont les cellules cancéreuses du sein, du colon et des poumons. Ce conjugué ou un composé à action analogue inhibant la croissance cellulaire et agissant via un récepteur de fixation de la saposine C peut servir à réduire la croissance cellulaire et/ou à traiter les troubles de la prolifération du stroma (par exemple l'hyperplasie bénigne de la prostate, l'athérosclérose et les resténoses vasculaires).

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