A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01)
Patent
CA 2522833
Compositions and methods for treating subjects with disorders characterized by hyper-proliferating cells such as tumors and cancers are provided. The compositions comprise agents that are combinations of saposin C ( or prosaposin-related polypeptides and dioleoylphosphatidylserine ( or inner leaflet components ). This anti-tumor agent is administered in the methods of the invention according to a dosing regimen. Administering an agent of the invention results in a positive therapeutic response in a subject with a tumor.
L'invention concerne des compositions et des méthodes permettant de traiter des sujets souffrant de troubles caractérisés par une hyperprolifération de cellules, comme dans le cas de tumeurs et de cancers. Les compositions comprennent des agents qui sont des combinaisons de saposine C (ou de polypeptides apparentés à la prosaposine) et de dioléoylphosphatidylsérine (ou de constituants de lamelle intérieure). Cet agent antitumoral est administré dans le cadre de méthodes de l'invention, selon un schéma posologique. L'administration d'un agent de l'invention induit une réponse thérapeutique positive chez un sujet atteint d'une tumeur.
Children's Hospital & Medical Center
Macpherson Leslie & Tyerman Llp
LandOfFree
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