Sarp-1 fusion proteins and uses thereof

Details Sarp-1 fusion proteins and uses thereof Sarp-1 fusion proteins and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01)

Patent

CA 2707735

The invention relates to a fusion protein comprising a mature SARP-1 polypeptide without the Netrindomain, the fusion protein further comprising an Fc region of an immunoglobulin, wherein the fusion protein lacks certain N-terminal amino acids of the mature SARP-1 polypeptide. The invention further relates to the use of said fusion protein fortreating cancer, a fibrotic disorder or a cardiovascular disorder.

L'invention concerne une protéine de fusion qui comprend un polypeptide SARP-1 mature sans le domaine de la nétrine, la protéine de fusion comprenant également une région Fc d'une immunoglobuline et certains acides aminés N-terminaux du polypeptide SARP-1 mature n'étant pas présents dans la protéine de fusion. L'invention concerne également l'utilisation de ladite protéine de fusion pour le traitement du cancer, d'un trouble fibrotique ou d'un trouble cardiovasculaire.

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