Saturated and unsaturated abietane derivatives, derived...

C - Chemistry – Metallurgy – 07 – C

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C07C 243/36 (2006.01) A61K 47/48 (2006.01) C07D 207/46 (2006.01) C07K 5/06 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2339102

The invention concerns a saturated or unsaturated abietane derivative of general formula (I) wherein: Z is selected among -COOR?5¿, -CONR?1¿R?2¿, -COONR?3¿R?4¿, -COR?6¿, -CON, -COOR?5¿, -CHOHR?7¿, -SR?8¿, -OR?8¿, -CN, -CNO, -CNS, -NCO, -NCS, -R?1¿R?2¿CR?9¿; wherein R?1¿, R?2¿, R?3¿ and R?4¿ represent a hydrogen atom, a C¿1?-C¿10? alkyl, a C¿6?-C¿20? aryl optionally substituted; a C¿7?-C¿10? alkene; a C¿1?-C¿10? alkyne; an aminoacyl or peptidyl optionally substituted; or R?1¿ and R?2¿ or R?3¿ and R?4¿ together can form a cycle or a heterocycle; R?5¿ represents a hydrogen, a C¿1?-C¿10? alkyl, a C¿1?-C¿10? alkene, a C¿1?-C¿10? alkyne; an aryl, optionally substituted into C¿6?-C¿20?; R?6¿ represents a hydrogen, a halogen, a C¿1?-C¿10? alkyl, a C¿1?-C¿10? alkene, a C¿1?-C¿10? alkyne, an aryl optionally substituted into C¿6?-C¿20?; R?7¿ represents a hydrogen, a C¿1?-C¿10? alkyl, a C¿1?-C¿10? alkene, a C¿1?-C¿10? alkyne; R?8¿ represents a hydrogen, a C¿1?-C¿10? alkyl, a C¿1?-C¿10? alkene, a C¿1?-C¿10? alkyne; and R?9¿ is selected among -CN, -CNO, -CNS, -NCO, and -NCS. The invention also concerns a derived conjugate and the use of said derivative and said conjugate in a diagnostic composition, a reagent and a device.

L'invention concerne un dérivé saturé ou insaturé de l'abiétane de formule générale (I), dans laquelle Z est choisi parmi -COOR?5¿, -CONR?1¿R?2¿, -COONR?3¿R?4¿, -COR?6¿, -CON, -COOR?5¿, -CHOHR?7¿, -SR?8¿, -OR?8¿, -CN, -CNO, -CNS, -NCO, -NCS, -R?1¿R?2¿CR?9¿; où R?1¿, R?2¿, R?3¿ et R?4¿ représentent un atome d'hydrogène, un alkyle en C¿1?-C¿10?, un aryle en C¿6?-C¿20?, éventuellement substitué; un alcène en C¿7?-C¿10?; un alcyne en C¿1?-C¿10?; un aminoacyle ou peptidyle éventuellement substitué, ou R?1¿ et R?2¿ ou R?3¿ et R?4¿ ensemble peuvent former un cycle ou un hétérocycle; R?5¿ représente un hydrogène, un alkyle en C¿1?-C¿10?, un alcène en C¿1?-C¿10?, un alcyne en C¿1?-C¿10?, un aryle, éventuellement substitué en C¿6?-C¿20?; R?6¿ représente un hydrogène, un halogène, un alkyle en C¿1?-C¿10?, un alcène en C¿1?-C¿10?, un alcyne en C¿1?-C¿10?, un aryle, éventuellement substitué en C¿6?-C¿20?; R?7¿ représente un hydrogène, un alkyle en C¿1?-C¿10?, un alcène en C¿1?-C¿10?, un alcyne en C¿1?-C¿10?; R?8¿ représente un hydrogène, un alkyle en C¿1?-C¿10?, un alcène en C¿1?-C¿10?, un alcyne en C¿1?-C¿10?; et R?9¿ est choisi parmi -CN, -CNO, -CNS, -NCO et -NCS; un conjugué dérivé et l'utilisation de ce dérivé et de ce conjugué dans une composition diagnostique, un réactif et un dispositif.

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