C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2735177
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
La présente invention concerne des composés de formule I : et des sels pharmaceutiquement acceptables ou des tautomères de ceux-ci qui sont des inhibiteurs de la voie Sonic Hedgehog, en particulier des antagonistes de Smo. Par conséquent, les composés de cette invention sont utiles pour le traitement de maladies associées à une activation anormale de la voie hedgehog, comprenant le cancer, par exemple lépithélioma basocellulaire, le médulloblastome, les cancers de la prostate, pancréatique, du sein, du côlon, des os et du poumon à petites cellules, et des cancers du tractus gastro-intestinal supérieur.
Branca Danila
Ferrigno Federica
Hernando Jose Ignacio Martin
Jones Philip
Kinzel Olaf
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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