Scaffold matrix and tissue maintaining systems

Details Scaffold matrix and tissue maintaining systems Scaffold matrix and tissue maintaining systems

C - Chemistry, Metallurgy

12

M

C12M 3/02 (2006.01) A61F 2/28 (2006.01) A61L 27/36 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) A61F 2/30 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2378209

The invention concerns a device with a constant perfusion system for maintenance of viable cells, tissues and composite implants, which involves a pressure generator for producing rhythmic pulses of pressure on the biological specimen. All the operative parameters of the system are controllable, easily manipulated. The invention further concerns a scaffold which is used as a growth supportive base for various cells and tissue explants from three- dimensional tissue comprising naturally derived connective or skeletal tissue cross-linked with one of the following: hyaluronic acid, proteoglycans, glycosaminolycans, chondroitin sulfates, heparan sulfates, heparins and dextran sulfates.

L'invention concerne un dispositif équipé d'un système de perfusion constante, qui sert à conserver des cellules, des tissus et des implants composites viables. Le dispositif comporte un générateur de pression pour produire des impulsions rythmiques de pression sur l'échantillon biologique. Tous les paramètres de commande du système peuvent être réglés et manipulés facilement. L'invention concerne en outre un échafaudage qui est utilisé comme base de support de croissance pour diverses cellules et explants tissulaires issus d'un tissu en trois dimensions, comprenant du tissu conjonctif ou squelettique naturel réticulé à l'une des substances suivantes: acide hyaluronique, protéoglycans, glycosaminoglycans, chondroïtine-sulfates, héparane sulfates, héparines et dextrane sulfates.

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