C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/18 (2006.01)
Patent
CA 2630645
A scalable process for the preparation of a rapamycin 42-ester by reacting a rapamycin 42-ester boronate with a diol and purifying crude rapamycin 42-ester by recrystallization and treatment with a diol is provided. Also provided is a method for isolating and purifying a rapamycin 42-ester boronate from mother liquors comprising acetone and rapamycin contaminants.
La présente invention concerne un procédé évolutif pour la préparation d'un 42-ester de rapamycine en faisant réagir un borate de 42-ester de rapamycine avec un diol et en purifiant 42-ester de rapamycine brut par recristallisation et traitement avec un diol. La présente invention concerne en outre un procédé pour isoler et purifier un borate de 42-ester de rapamycine à partir de liqueurs mères comprenant de l'acétone et des contaminants de rapamycine.
Coughlin Clifford William
Farina James S.
Michaud Adam P.
Pilcher Anthony
Sahli Ayman
Torys Llp
Wyeth
LandOfFree
Scalable process for the preparation of a rapamycin 42-ester... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Scalable process for the preparation of a rapamycin 42-ester..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Scalable process for the preparation of a rapamycin 42-ester... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1485247