Scanning suspension comprising a particle with a diameter of...

A - Human Necessities – 61 – K

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Details

A61K 49/18 (2006.01) A61K 51/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2491484

The invention provides a scanning suspension comprising a particle which is capable of at least in part disturbing a magnetic field, wherein said particle comprises a diameter of at least 1 ~m, and use thereof for obtaining a scanning image. Preferably, said particle comprises holmium and a composition capable of essentially maintaining its structure during irradiation. A particle of the invention is suitable for preparing a kit of parts, comprising a diagnostic and a therapeutic composition which both comprise particles of the invention with essentially the same chemical structure, wherein said therapeutic composition is more radioactive than said diagnostic composition. Said kit of parts is especially suitable for treatment of a tumour. Firstly, the distribution of a particle of the invention within an individual can be determined with a scanning image obtained with said scanning composition. Subsequently, a radioactive therapeutic composition can be administered, wherein a suitable dose of said therapeutic composition is derived from said scanning image.

La présente invention concerne une suspension de balayage comprenant une particule qui est capable d'au moins partiellement distribuer un champ magnétique et qui présente un diamètre d'au moins 1 µm, ainsi que l'utilisation de cette suspension afin d'obtenir une image de balayage. Cette particule comprend de préférence de l'holmium et une composition capable de conserver sensiblement sa structure lors de l'irradiation. Une particule selon cette invention est utilisée pour préparer un ensemble de pièces, présentant une composition diagnostique et une composition thérapeutique qui comprennent des particules selon cette invention, de structure chimique sensiblement identique, ladite composition thérapeutique étant plus radioactive que ladite composition diagnostique. Ledit ensemble de pièces est utilisé pour traiter une tumeur. La distribution d'une particule selon cette invention chez un individu peut être déterminée à l'aide d'une image de balayage obtenue grâce à ladite composition de balayage. Une composition thérapeutique radioactive peut ensuite être administrée, la dose adéquate de composition thérapeutique étant déterminée à partir de l'image de balayage.

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