Scavenger receptor protein and antibody thereto

Details Scavenger receptor protein and antibody thereto Scavenger receptor protein and antibody thereto

C - Chemistry, Metallurgy

07

K

167/103, 530/13,

C07K 14/705 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/00 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340977

A substantially pure receptor protein capable of binding acetylated low density lipoprotein and oxidized low density lipoprotein is disclosed herein. This protein is characterized by having a molecular weight of about 220,000 daltons, and an affinity for oxidized low density lipoprotein and acetylated low density lipoprotein. Further, it is an integral membrane protein which includes a collagen domain. Proteins having an affinity for the receptor protein as well as DNA sequences encoding at least a portion of the receptor protein are also disclosed herein. In addition, devices for purification purposes and methods for detecting atherosclerotic plaques are described, both of which utilize the receptor protein or binding proteins thereto.

613991

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