Scf extract containing cardiac glycoside

Details Scf extract containing cardiac glycoside Scf extract containing cardiac glycoside

A - Human Necessities

61

K

A61K 36/185 (2006.01)

Patent

CA 2609808

A supercritical fluid (SCF) extract of a cardiac glycoside-containing plant mass is provided. The extract can be included in a pharmaceutical composition containing an extract-solubilizing amount of solubilizer. Oleandrin is included within the extract when a cardiac glycoside-containing plant, such as Nerium oleander, is extracted by SCF extraction. The extract can also contain one or more other SCF extractable pharmacologically active agents. The composition can be used to treat a wide range of disorders that are therapeutically responsive to a cardiac glycoside.

L'invention a pour objet un extrait de fluide supercritique (EFS) d'une masse végétale renfermant du glucose cardiotonique. L'extrait peut être introduit dans une composition pharmaceutique contenant une dose de solubilisation d'extrait. On introduit de l'oléandrine dans l'extrait lorsque l'on extrait une plante, du type oléandre, renfermant du glucose cardiotonique, par extraction par fluide supercritique (EFS). L'extrait peut également renfermer un ou plusieurs agents pharmacologiquement actifs extractibles par ESF. La composition peut être utilisée dans le traitement d'une gamme étendue de troubles réagissant thérapeutiquement à un glucoside cardiotonique.

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