Schizophrenia associated genes, proteins and biallelic markers

Details Schizophrenia associated genes, proteins and biallelic markers Schizophrenia associated genes, proteins and biallelic markers

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2361408

The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31- q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.

L'invention porte sur les marqueurs bialléliques des gènes humains, polynucléotides et polypeptides sbg1, g34665, sbg2, g35017 et g35018, et les marqueurs bialléliques du chromosome humain 13q31-q33. L'invention porte également sur l'association établie entre la schizophrénie et les troubles bipolaires d'une part, et les marqueurs bialléliques des gènes et séquences nucléotidiques sbg1, g34665, sbg2, g35017 et g35018 d'autre part. L'invention porte en outre sur des moyens d'identification de composés utiles pour le traitement de la schizophrénie, des troubles bipolaires et des maladies associées, sur des moyens de déterminer la prédisposition d'individus auxdites maladies, ainsi que sur des moyens de diagnostiquer ou pronostiquer lesdites maladies.

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