C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) G01N 33/542 (2006.01) G01N 33/60 (2006.01)
Patent
CA 2448000
The present invention describes novel methods, assays and kits for identifying and / or quantifying Aminoglycoside Binding Molecules (ABMs), enzymes modifying such molecules, and compounds modulating the interaction between ABMs and either enzymes or aminoglycosides in a sample, by exploiting the scintillation proximity effect. The invention, which makes use of aminoglycoside-coated scintillating supports, which previously had not been known for use as a general tool in this area, can be adapted to high throughput screening formats. Depending on the criteria and/or reactants used in the preparation of the sample, the method can be applied to various embodiments, wherein samples prepared with the same criteria are compared by measuring the emission generated in each sample due to the proximity between the scintillating support and the radiolabeled ABM.
L'invention concerne de nouveaux procédés, dosages et nécessaires destinés à identifier et/ou à quantifier des molécules de liaison aminoglycoside (ABM), d'enzymes modifiant ces molécules, et de composés modulant l'interaction entre les ABM et soit les enzymes soit les aminoglycosides, par exploitation de l'effet de la scintillation par proximité. L'invention, qui utilise des supports scintillants revêtus d'aminoglycosides, peut être adaptée à des profils d'évaluation à haut rendement.
Camps Montserrat
Chabert Christian
Martin Thierry
Perrin Dominique
Rommel Christian
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
Merck Serono Sa
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