Scoring estrogen and progesterone receptors expression based...

G - Physics – 06 – T

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G06T 7/00 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2511608

A method of scoring Oestrogen and Progesterone Receptors expression (ER and PR) from histological images determines the percentage of brown image blob area in total blob area and derives percentage thresholds to quantify scoring. Brown blob area proportion is then compared with the thresholds to provide a first contribution to scoring of ER or PR. The number of relatively dark pixels is then counted, pixel number thresholds are determined to quantify scoring, and the number of relatively dark pixels is compared with the thresholds to provide a second contribution to scoring of ER or PR. The two contributions are then added to provide an overall scoring in the range 0 to 8 which may be taken as a final score or it may be scaled to a conventional range 0 to 3.

L'invention concerne un procédé de notation de l'expression des récepteurs oestrogéniques et de la progestérone (ER et PR) à partir d'images histologiques, permettant de déterminer le pourcentage de taches brunes sur une image et de dériver des pourcentages limites pour quantifier la notation. La proportion de taches brunes est ensuite comparée aux limites pour fournir une première contribution à la notation des ER ou PR. Le nombre de pixels relativement foncés est ensuite compté, les limites des nombres de pixels sont déterminées pour quantifier la notation, et le nombre de pixels relativement foncés est comparé aux limites pour fournir une seconde contribution à la notation des ER ou PR. Les deux contributions sont ensuite additionnées pour fournir une notation globale comprise entre 0 et 8 pouvant être considérée comme une notation finale ou ramenée à une marge conventionnelle comprise entre 0 et 3.

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