Scorpion toxins

Details Scorpion toxins Scorpion toxins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/435 (2006.01) C12N 1/00 (2006.01) C12N 15/82 (2006.01) C12N 15/86 (2006.01) C12N 15/866 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2372701

This invention relates to an isolated nucleic acid fragment encoding scorpion toxins that are Na-channel modifiers. The invention also relates to the construction of a chimeric gene encoding all or a substantial portion of the Na-channel modifier, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the Na-channel modifier in a transformed host cell.

La présente invention concerne un fragment d'acide nucléique isolé codant des toxines du scorpion qui sont des gènes modificateurs du canal sodique. L'invention concerne également la construction d'un gène chimérique, codant tout ou une grande partie du gène modificateur du canal sodique, dans une orientation sens ou antisens, dans laquelle l'expression du gène chimérique permet de produire des niveaux altérés du gène modificateur du canal sodique, dans une cellule hôte transformée.

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