Screen for ultraspiracle inhibitors

Details Screen for ultraspiracle inhibitors Screen for ultraspiracle inhibitors

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2257110

The invention relates to the identification of inhibitors of "orphan" nuclear receptors, or receptors for which no natural ligand is known. The invention relates to the Ultraspiracle protein, or Usp, of Drosophila melanogaster and homologues thereof in other insect species. The invention provides for identifying compounds, variant nuclear proteins, and other auxiliary proteins that interfere with Usp function. Usp inhibitory compounds are useful as insecticides or as lead compounds for the development of insecticides.

L'invention concerne l'identification d'inhibiteurs de récepteurs nucléaires "orphelins", ou de récepteurs pour lesquels on ne connaît aucun ligand naturel. L'invention concerne la protéine Ultraspiracle, ou Usp, de Drosophila mélanogaster et ses homologues dans d'autres espèces d'insectes. L'invention permet d'identifier des composés, des protéines nucléaires variantes, et d'autres protéines auxiliaires qui interfèrent avec la fonction Usp. Des composés inhibiteurs de la fonction Usp sont utiles comme insecticides ou comme composés principaux pour le développement d'insecticides.

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