C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2237717
The present invention provides a method to design compounds that mimic the effects of Pbx in stabilizing STF-1 binding. Using well-known DNA binding assays, a person having ordinary skill in this art would be able to screen compounds to determine drugs effective in promoting STF-1 binding to DNA. In this way, one will be able to discover new compounds useful in stimulating somatostatin and insulin production.
L'invention concerne un procédé permettant de mettre au point des composés mimant l'action de la Pbx dans la stabilisation de la liaison de la STF-1. Par des méthodes de criblage bien connues de la liaison de l'ADN, une personne expérimentée peut cribler des composés afin de déterminer les médicaments favorisant la fixation de la STF-1 sur l'ADN. Ceci permet de découvrir de nouveaux composés utiles pour stimuler la production de somatostatine et d'insuline.
Montminy Marc R.
Peers Bernard
Borden Ladner Gervais Llp
Research Development Foundation
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