C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2434866
An assay comprising cells containing DNA which encodes a fusion protein containing a signal peptide fused and/or linked to a reporter gene protein for the identification of compounds which interfere with the process of cotranslational translocation and with the production of secreted or membrane protein.
L'invention concerne une méthode faisant appel à des cellules contenant de l'ADN codant pour une protéine de fusion contenant un peptide signal fusionné avec et/ou lié à une protéine de gène rapporteur, cette méthode permettant d'identifier des composés entravant le processus de translocation cotraductionnelle et la production de protéine sécrétée ou membranaire.
Dascher-Nadel Christiane
Lindley Ivan James Dalton
Marquardt-Gehrke Kathi Franziska
Fetherstonhaugh & Co.
Novartis Ag
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