C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2092000
2092000 9205286 PCTABS00011 A method for the identification of compounds as inhibitors of oncoprotein action is described. A compound is identified as an inhibitor of oncoprotein action based on its ability to modulate the transcription of a reporter gene. Transcription of the reporter gene is dependent upon the binding of a fusion oncoprotein to a specific DNA binding element positioned upstream of the reporter gene promoter. The fusion oncoprotein contains a transcriptional regulatory domain from an oncoprotein and a DNA binding domain from a different protein.
Anderson Catherine
Brent Roger
Golemis Erica
Lech Karen F.
Anderson Catherine
Brent Roger
Cassan Maclean
Golemis Erica
Lech Karen F.
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