G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/576 (2006.01)
Patent
CA 2465731
The present invention features methods of screening for compounds that inhibit HCV binding to a cell, methods of inhibiting HCV entry into a cell, and methods of actively or prophylactically treating against an HCV infection. The different methods are based on the identification of the scavenger receptor class B type I as a target site for HCV E2 binding to a cell.
La présente invention concerne des méthodes de criblage destinées à identifier des composés qui inhibent la fixation du VHC à une cellule. Elle concerne également des méthodes pouvant inhiber la pénétration du virus dans une cellule; et des méthodes de traitement actif ou prophylactique contre une infection à VHC. Ces différentes méthodes sont fondées sur l'identification du récepteur macrophage de classe B, type I, comme site cible de liaison du VHC E2 à une cellule.
Cortese Riccardo
Scarselli Elisa
Vitelli Alessandra
Gowling Lafleur Henderson Llp
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
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