Screening for nuc inhibitors

Details Screening for nuc inhibitors Screening for nuc inhibitors

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2193685

This invention provides methods for screening for agents useful for treatment of diseases and pathological conditions affected by the level of NUC protein activity. These agents reduce or relieve the repression of PPAR.alpha. protein and TR protein transcription activation activity by NUC protein. The selected novel or unique agents can be used to treat hyperlipidemia, hypercholesteremia and hyperlipoproteinemia.

L'invention concerne des méthodes de criblage d'agents utilisés pour le traitement de maladies et d'états pathologiques affectés par le niveau d'activité de la protéine NUC. Ces agents réduisent ou atténuent la répression de l'activité d'activation transcriptionnelle de la protéine PPAR.alpha. et de la protéine TR par la protéine NUC. Ces agents nouveaux ou uniques, sélectionnés, peuvent être utilisés pour traiter l'hyperlipidémie, l'hypercholestérolémie et l'hyperlipoprotéinémie.

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