Screening method

Details Screening method Screening method

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 16/28 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/94 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2399052

A method of screening a compound, which is capable of changing the binding properties of neuromedin U or its salt to TGR-1 or its salt, or its salt characterized by using neuromedin U or a derivative or a salt thereof and TGR- 1 or a salt thereof. This method is usable in screening preventives and remedies for hypertension, stress diseases, etc. TGR-1 antagonists are useful as preventives and remedies for hypertension, stress diseases, etc.

On décrit un procédé de criblage d'un composé qui est capable de changer les propriétés de liaison de la neuromédine U ou de son sel en TGR-1 ou son sel et qui se caractérise en ce qu'on utilise de la neuromédine U ou un dérivé ou un sel de cette dernière et du TGR-1 ou son sel. Ce procédé peut être utilisé pour cribler des substances prophylactiques et des médicaments contre l'hypertension, les maladies liées au stress et autres. Les antagonistes TGR-1 sont utiles en tant que substances prophylactiques et médicaments contre l'hypertension, les maladies liées au stress et autres.

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