Screening method based on siah-numb interaction

Details Screening method based on siah-numb interaction Screening method based on siah-numb interaction

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/435 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2432683

The invention concerns methods for detecting, identifying and/or screening compounds capable of being used for treating cancers and certain neurodegenerative diseases, related to dysfunction in the regulation of tumour suppression and/or apoptosis, in the biological chain of p53, said methods being based on Siah-1/Numb interaction.

La pr~sente invention a pour objet des m~thodes de d~tection, identification et/ou criblage de compos~s pouvant notamment Útre utilis~s pour le traitement des cancers ou de certaines maladies neuro-d~g~n~ratives, li~s ~ des d~r~glements dans la r~gulation de la suppression tumorale et/ou de l'apoptose, dans la cha~ne biologique de p53, lesdits proc~d~s ~tant bas~s sur l'interaction entre Siah-1 et Numb.

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