C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) A61K 45/00 (2006.01) A61P 1/00 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2653929
It is intended to provide a screening tool and a screening method for obtaining a substance useful as a preventive and/or therapeutic agent for a disease associated with an abnormality of production or secretion of 5-HT including a gastrointestinal disease, and a preventive and/or therapeutic agent for a disease associated with an abnormality of production or secretion of 5-HT including a gastrointestinal disease. Examples of the gastrointestinal disease of the invention include constipation irritable bowel syndrome, functional dyspepsia, constipation, diarrhea irritable bowel syndrome, diarrhea and vomiting.
L'invention porte sur un outil de criblage et un procédé de criblage pour obtenir une substance utile en tant qu'agent préventif et/ou thérapeutique pour une maladie associée à une anomalie de production ou de sécrétion de 5-HT comprenant une maladie gastro-intestinale, et sur un agent préventif et/ou thérapeutique pour une maladie associée à une anomalie de production ou de sécrétion de 5-HT comprenant une maladie gastro-intestinale. Des exemples de la maladie gastro-intestinale de l'invention comprennent le syndrome du côlon irritable avec constipation, la dyspepsie fonctionnelle, la constipation, le syndrome du côlon irritable avec diarrhée, la diarrhée et les vomissements.
Doihara Hitoshi
Kojima Ryosuke
Nozawa Katsura
Shoda Eri
Astellas Pharma Inc.
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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