Screening method using the rzr receptor family

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) A61K 31/40 (2006.01) A61K 31/425 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07K 14/705 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2182700

The current invention concerns the use of a receptor from the RZR/ROR receptor family or of a functional fragment thereof in a test of a compound for anti-autoimmune, anti-arthritic, anti-tumor, melatonin-like and/or melatonin-antagonistic activity and the production of a receptor ligand complex comprising raid receptor or a functional fragment thereof and a ligand of said receptor. Described is also a method for testing compounds for said activity (screening for ligands) and the active compounds identified therewith.

L'invention concerne l'utilisation d'un récepteur provenant de la famille de récepteurs RZR/ROR, ou d'un fragment fonctionnel de celui-ci, dans un test effectué sur un composé pour déterminer son activité anti-auto-immune, anti-arthritique, anti-tumorale, de type mélatonine et/ou son activité dirigée contre la mélatonine; l'invention concerne également la production d'un complexe récepteur ligand comprenant ledit récepteur ou un fragment fonctionnel de celui-ci ainsi qu'un ligand dudit récepteur. L'invention concerne encore un procédé destiné à tester les composés pour déterminer leur activité (criblage de ligands) ainsi que les composés actifs identifiés à l'aide de ce procédé.

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