Screening methods employing insects with blood brain barrier

Details Screening methods employing insects with blood brain barrier Screening methods employing insects with blood brain barrier

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2736844

There is provided insect models that are aimed to reflect vertebrate blood- brain barrier (BBB) penetration. Investigation of BBB penetration is extremely important in drug discovery; successful CNS drugs have to cross the BBB, while BBB penetration may cause unwanted side effects for peripheral acting drugs. Specifically, the present invention relates to the use of insects in screening for substances with a biological effect on the brain or central nervous system and/or effect on a disease or disorder of the brain or central nervous system. It further relates to use of such insects in screening for substances that have a desired biological activity and which do not cross the blood brain barrier.

L'invention porte sur des modèles d'insecte qui visent à refléter la pénétration de la barrière hémato-encéphalique (BBB) par des vertébrés. La recherche de la pénétration de la BBB est extrêmement importante pour la découverte de médicaments ; des médicaments pour le système nerveux central réussis doivent traverser la BBB, tandis que la pénétration de la BBB peut provoquer des effets secondaires non souhaités pour des médicaments agissant de manière périphérique. De façon spécifique, la présente invention porte sur l'utilisation d'insectes dans le criblage pour des substances ayant un effet biologique sur le cerveau ou le système nerveux central et/ou un effet sur une maladie ou un trouble du cerveau ou du système nerveux central. L'invention porte en outre sur l'utilisation de tels insectes dans le criblage de substances qui ont une activité biologique souhaitée et qui ne traversent pas la barrière hémato-encéphalique.

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