Screening methods for bone morphogenetic mimetics

Details Screening methods for bone morphogenetic mimetics Screening methods for bone morphogenetic mimetics

G - Physics

01

N

G01N 33/68 (2006.01) C07K 14/51 (2006.01)

Patent

CA 2431552

Disclosed are methods for identifying agents which modulate the activity of bone morphogenetic protein-7. These methods for identifying agents utilize bone morphogenetic protein receptors, specifically the daf-4 receptor, and more specifically the extracellular domain of the daf-4 receptor. Agents identified by the methods are also described as well as compositions comprising the agents and methods of treating a subject using the agents or compositions.

Procédés servant à identifier des agents modulant l'activité de la protéine-7 morphogénétique osseuse. Ces procédés mettent en application des récepteurs de protéine morphogénétique osseuse, en particulier, le récepteur de daf-4 et, plus particulièrement, le domaine extracellulaire du récepteur de daf-4. Agents identifiés au moyen de ces procédés, ainsi que compositions contenant ces agents et procédés servant à traiter un individu au moyen de ces agents ou de ces compositions.

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